Moore's Law breaks down a bit after set date, i think. In any case, that's why i said bio-nanotechnology would be better for something like this, because with increased knowledge on reconstructing genetics, we will have much more options opened to us in that field.
We could have a moon base easily. Really no problem at all. The real issue is NASA's funding and the fact that the united states isn't quite giving innovation what it needs, while it still has the best resources to do those things. There are some things only NASA can do, but congress doesn't care much for them, it seems.