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1. Basic knowledge of PHP and SQL2. Basic knowledge of PHP and JavascriptMaybe I don't understand your question but the answers seem pretty fucking obvious?
Haven't use PDO myself. But afaik when with mysqli(-driver) you can communicate only with mysql databases, but with right PDO-driver you can use mysql, microsoft sql, postgresql, sqlite, etc. databases. So i think pdo's flexibility is one of it advantages. Correct me if i'm wrong.