whats the difference of using CLI or GUI? at the end it will be working with sockets , etc. 
Im looking for a way to give a variable to the inputs I tried:
 
dim newword as char
if textbox1.text = "starting to describe something new" + newword 'here Ive to do magic with 'the first known string
label1.text = "Ive learnt something new added to my memory ;)" 'or something cool 
end if
Try this,
        Dim asd As New Char or 
Dim asd As Char        If TextBox1.Text.Contains("blabla" + asd) Then
        Label1.Text = "blabla"
Else
        Label1.Text = "notblabla"
        End If
EDIT:
If that's what you're looking for.
EDIT again:
Use a text file as Resource, your text file could contain all the variables/words. Anyways that doesn't really matter if it's in the code, resource nor database. My opinion.